Developing a single-dose, intranasal, live-attenuated vaccine against COVID-19

Codagenix is a clinical stage synthetic biology company that uses software to recode the genomes of viruses, constructing live-attenuated vaccines or viruses to prevent viral infections or treat solid tumors. Codagenix’s recoded vaccine candidates are a perfect antigenic match to the target virus and induce a robust immune response to all viral antigens. For cancer, our nimble platform allows us to turn a virus into a potential oncolytic immuno-oncology therapies. Both programs rely on scalable, low-cost manufacturing.


The COVID-19 pandemic continues to spread in the U.S. and around the world. COVI-VAC is a single-dose, intranasal, live attenuated vaccine against COVID-19, generated using Codagenix’s proprietary deoptimization technology.

Safe and effective live-attenuated vaccines, presenting all target antigens

Target customized oncolytics to treat primary tumors and shrink off-site metastases


RSV hospitalizations among adults 65+ no vaccine

48.8 million

Flu cases in 2017-18, current vaccines <37% effective

1 in 8

US women (about 12%) will develop invasive breast cancer during lifetime.

Our breakthrough approach to live-attenuated virus design

1. Recode

2. Synthesize

3. Transfect

4. Recover

  • October 19, 2021

    Codagenix Announces Appointment of Two New Members to its Board of Directors

  • September 22, 2021

    Codagenix Announces Safety and Immunogenicity Data from Phase 1 COVID-19 Intranasal Vaccine Trial and Intent to Progress to Phase 2/3 Studies

    Novel intranasal vaccine candidate shows promise for immunity against COVID-19 and virus variants

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